Head to head, which interpretation was better:
X-Men:
*Professor X (Patrick Stewart vs. Cedric Smith)
*Cyclops (James Marsden vs. Norm Spencer)
*Wolverine (Hugh Jackman vs. Cal Dodd)
*Beast (Kelsey Grammer vs. George Buza)
*Gambit (Taylor Kitsch vs. Chris Potter) - I'm not going to bother including "fake Gambit", Tony Daniels that showed up in the last few episodes
*Storm (Halle Berry vs. Alison Sealy-Smith) - I'm not including Iona Morris (even though she did come back to play Storm in the "Secret Wars" episodes of Spider-Man) only because Sealy-Smith was Storm much longer
*Rogue (Anna Paquin vs. Lenore Zann)
*Jean Grey (Famke Janssen vs. Catherine Disher)
*Jubliee (Kea Wong vs. Alyson Court)
Spider-Man:
*Spider-Man/Peter Parker (Tobey Maguire vs. Christopher Daniel Barnes)
*Mary Jane Watson (Kirsten Dunst vs. Sara Ballantine)
*Harry Osborn (James Franco vs. Gary Imhoff)
*Aunt May Parker (Rosemary Harris vs. Linda Gary) - I know that Julie Bennett took over as the voice of Aunt May after Linda Gary passed away from brain cancer, but I'm going with Gary because she performed the voice much longer.
*J. Jonah Jameson (J.K. Simmons vs. Edward Asner)
*Uncle Ben Parker (Cliff Robertson vs. Brian Keith)
*Joe "Robbie" Robertson (Bill Nunn vs. Rodney Saulsberry)
*Gwen Stacy (Bryce Dallas Howard vs. Mary Kay Bergman) - I'm aware that the animated version of Gwen appeared in an "alternate universe" (since the producers weren't comfortable with regularly using a long dead character from the comics) in the last episode.
*Flash Thompson (Joe Manganiello vs. Patrick Labyorteaux)
*John Jameson (Daniel Gillies vs. Michael Horton)
*Green Goblin/Norman Osborn (Willem Dafoe vs. Neil Ross)
*Dr. Octopus/Otto Octavius (Alfred Molina vs. Efrem Zimbalist, Jr.)
*Venom/Eddie Brock (Topher Grace vs. Hank Azaria)
*Lizard/Dr. Curt Connors (Dylan Baker vs. Joseph Campanella)
Fantastic Four
*Reed Richards/Mr. Fantastic: Ioan Gruffudd vs. Beau Weaver
*Susan Storm/Invisible Woman: Jessica Alba vs. Lori Alan
*Ben Grimm/Thing: Michael Chiklis vs. Chuck McCann
*Johnny Storm/Human Torch: Chris Evans vs. Quinton Flynn - I chose Quinton Flynn over Brain Austin Green (the voice of Johnny Storm during the first season) because Flynn's take over coincided with the superior second season.
*Dr. Doom: Julian McMahon vs. Simon Templeton
*Alicia Masters: Kerry Washington vs. Pauline Lomas
*Silver Surfer: Doug Jones/Laurence Fishburne vs. Robin Sachs or Paul Essiembre (the voice of Norrin Radd on the solo Silver Surfer animated series) - I know that Edward Albert did the voice of the Surfer during the second season, but that was only for one episode compared to three for Robin Sachs.
*Frankie Raye: Beau Garrett vs. Lisa Miller McGee or Tara Rosling (from the solo Silver Surfer animated series)
Iron Man:
*Iron Man/Tony Stark: Robert Downey Jr. vs. Robert Hays
*War Machine/Jim Rhodes: Terrence Howard or Don Cheadle vs. James Avery or Dorian Harewood
*Justin Hammer: Sam Rockwell vs. Tony Steedman or Efrem Zimbalist Jr.
*Whiplash (Blacklash)/Crimson Dynamo: Mickey Roruke vs. James Avery or Dorian Harewood (Whiplash/Blacklash); William Hootkins or Stu Rosen (Crimson Dynamo)
I know that Nick Fury appeared on the Iron Man animated series also, but I'm leaving him off because that Nick Fury is the 616 version compared to the "Ultimate" version from the live-action movies.
Incredible Hulk:
*Bruce Banner: Eric Bana or Edward Norton vs. Neal McDonough
*Betty Ross: Jennifer Connelly or Liv Tyler vs. Genie Francis or Philece Sampler
*Thunderbolt Ross: Sam Elliott or William Hurt vs. John Vernon
*Doc Samson: Ty Burrell vs. Shadoe Stevens
*Emil Blonsky/Abomination: Tim Roth vs. Richard Moll or Kevin Schon
*Samuel Sterns/The Leader: Tim Blake Nelson vs. Matt Frewer
*Glenn Talbot: Josh Lucas vs. Kevin Schon
Blade:
*Blade: Wesley Snipes vs. J.D. Hall
*Whistler: Kris Kristofferson vs. Malcolm McDowell or Oliver Muirhead
*Vanessa Brooks/Mirium: Sanaa Lathan vs. Nichele Nichols
Daredevil:
*Matt Murdock/Daredevil: Ben Affleck vs. Bill Smitrovich (the voice of DD on Fantastic Four) or Edward Albert (the voice of DD on Spider-Man)
*Wilson Fisk/Kingpin: Michael Clarke Duncan vs. Roscoe Lee Browne
The Punisher:
*Frank Castle: Dolph Lundgren, Thomas Jane or Ray Stevenson vs. John Beck
*Microchip: Wayne Knight vs. Robert Axelrod
Ghost Rider:
*Ghost Rider: Nicholas Cage vs. Richard Grieco - The animated version of Ghost Rider is apparently, the Danny Ketch version whereas Nicholas Cage played the Johnny Cage version in the movie.
X-Men:
*Professor X (Patrick Stewart vs. Cedric Smith)
*Cyclops (James Marsden vs. Norm Spencer)
*Wolverine (Hugh Jackman vs. Cal Dodd)
*Beast (Kelsey Grammer vs. George Buza)
*Gambit (Taylor Kitsch vs. Chris Potter) - I'm not going to bother including "fake Gambit", Tony Daniels that showed up in the last few episodes
*Storm (Halle Berry vs. Alison Sealy-Smith) - I'm not including Iona Morris (even though she did come back to play Storm in the "Secret Wars" episodes of Spider-Man) only because Sealy-Smith was Storm much longer
*Rogue (Anna Paquin vs. Lenore Zann)
*Jean Grey (Famke Janssen vs. Catherine Disher)
*Jubliee (Kea Wong vs. Alyson Court)
Spider-Man:
*Spider-Man/Peter Parker (Tobey Maguire vs. Christopher Daniel Barnes)
*Mary Jane Watson (Kirsten Dunst vs. Sara Ballantine)
*Harry Osborn (James Franco vs. Gary Imhoff)
*Aunt May Parker (Rosemary Harris vs. Linda Gary) - I know that Julie Bennett took over as the voice of Aunt May after Linda Gary passed away from brain cancer, but I'm going with Gary because she performed the voice much longer.
*J. Jonah Jameson (J.K. Simmons vs. Edward Asner)
*Uncle Ben Parker (Cliff Robertson vs. Brian Keith)
*Joe "Robbie" Robertson (Bill Nunn vs. Rodney Saulsberry)
*Gwen Stacy (Bryce Dallas Howard vs. Mary Kay Bergman) - I'm aware that the animated version of Gwen appeared in an "alternate universe" (since the producers weren't comfortable with regularly using a long dead character from the comics) in the last episode.
*Flash Thompson (Joe Manganiello vs. Patrick Labyorteaux)
*John Jameson (Daniel Gillies vs. Michael Horton)
*Green Goblin/Norman Osborn (Willem Dafoe vs. Neil Ross)
*Dr. Octopus/Otto Octavius (Alfred Molina vs. Efrem Zimbalist, Jr.)
*Venom/Eddie Brock (Topher Grace vs. Hank Azaria)
*Lizard/Dr. Curt Connors (Dylan Baker vs. Joseph Campanella)
Fantastic Four
*Reed Richards/Mr. Fantastic: Ioan Gruffudd vs. Beau Weaver
*Susan Storm/Invisible Woman: Jessica Alba vs. Lori Alan
*Ben Grimm/Thing: Michael Chiklis vs. Chuck McCann
*Johnny Storm/Human Torch: Chris Evans vs. Quinton Flynn - I chose Quinton Flynn over Brain Austin Green (the voice of Johnny Storm during the first season) because Flynn's take over coincided with the superior second season.
*Dr. Doom: Julian McMahon vs. Simon Templeton
*Alicia Masters: Kerry Washington vs. Pauline Lomas
*Silver Surfer: Doug Jones/Laurence Fishburne vs. Robin Sachs or Paul Essiembre (the voice of Norrin Radd on the solo Silver Surfer animated series) - I know that Edward Albert did the voice of the Surfer during the second season, but that was only for one episode compared to three for Robin Sachs.
*Frankie Raye: Beau Garrett vs. Lisa Miller McGee or Tara Rosling (from the solo Silver Surfer animated series)
Iron Man:
*Iron Man/Tony Stark: Robert Downey Jr. vs. Robert Hays
*War Machine/Jim Rhodes: Terrence Howard or Don Cheadle vs. James Avery or Dorian Harewood
*Justin Hammer: Sam Rockwell vs. Tony Steedman or Efrem Zimbalist Jr.
*Whiplash (Blacklash)/Crimson Dynamo: Mickey Roruke vs. James Avery or Dorian Harewood (Whiplash/Blacklash); William Hootkins or Stu Rosen (Crimson Dynamo)
I know that Nick Fury appeared on the Iron Man animated series also, but I'm leaving him off because that Nick Fury is the 616 version compared to the "Ultimate" version from the live-action movies.
Incredible Hulk:
*Bruce Banner: Eric Bana or Edward Norton vs. Neal McDonough
*Betty Ross: Jennifer Connelly or Liv Tyler vs. Genie Francis or Philece Sampler
*Thunderbolt Ross: Sam Elliott or William Hurt vs. John Vernon
*Doc Samson: Ty Burrell vs. Shadoe Stevens
*Emil Blonsky/Abomination: Tim Roth vs. Richard Moll or Kevin Schon
*Samuel Sterns/The Leader: Tim Blake Nelson vs. Matt Frewer
*Glenn Talbot: Josh Lucas vs. Kevin Schon
Blade:
*Blade: Wesley Snipes vs. J.D. Hall
*Whistler: Kris Kristofferson vs. Malcolm McDowell or Oliver Muirhead
*Vanessa Brooks/Mirium: Sanaa Lathan vs. Nichele Nichols
Daredevil:
*Matt Murdock/Daredevil: Ben Affleck vs. Bill Smitrovich (the voice of DD on Fantastic Four) or Edward Albert (the voice of DD on Spider-Man)
*Wilson Fisk/Kingpin: Michael Clarke Duncan vs. Roscoe Lee Browne
The Punisher:
*Frank Castle: Dolph Lundgren, Thomas Jane or Ray Stevenson vs. John Beck
*Microchip: Wayne Knight vs. Robert Axelrod
Ghost Rider:
*Ghost Rider: Nicholas Cage vs. Richard Grieco - The animated version of Ghost Rider is apparently, the Danny Ketch version whereas Nicholas Cage played the Johnny Cage version in the movie.